Gliclazide Tablet - Oral

Pronunciation: GLICK-luh-zide

Common Brand Name(s): Diamicron

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Uses

Gliclazide is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability.

Gliclazide belongs to the class of drugs known as sulfonylureas. It works by causing the release of your body's natural insulin.

How To Use

Read the Patient Information Leaflet provided by your pharmacist before you start using gliclazide and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

This medication comes in an immediate-release form and a modified-release form. The dosing is not the same. Do not use one form of this medication in place of the other.

If you are using the immediate-release form, take it by mouth with a meal, usually 1 to 3 times a day or as directed by your doctor. Most adults should take no more than 320 milligrams a day.

If you are using the modified-release form, take it once daily with breakfast or as directed by your doctor. Most adults should take no more than 120 milligrams a day. Do not crush or chew the modified-release form of this drug. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split modified-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet with a glass of cool water, without crushing or chewing.

The dosage is based on your medical condition and response to treatment. Your doctor will adjust your dose based on your blood sugar to find the best dose for you. Follow your doctor's directions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition persists or worsens (e.g., if blood sugar readings are too high or too low).

Side Effects

Nausea, stomach upset, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur:

  • signs of infection (e.g., persistent sore throat, fever)
  • easy bleeding/bruising
  • unusual/sudden weight gain
  • mental/mood changes
  • swelling of the hands/ankles/feet

Tell your doctor right away if any of these rare but very serious side effects occur:

  • severe stomach/abdominal pain
  • dark urine
  • unusual tiredness/weakness
  • yellowing eyes/skin

This medication can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms include cold sweat, blurred vision, dizziness, drowsiness, shaking, fast heartbeat, headache, fainting, tingling of the hands/feet, and hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor about the reaction right away. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking gliclazide, tell your doctor or pharmacist if you are allergic to it; or to other sulfonylureas such as glipizide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • use/abuse of alcohol
  • bleeding problems
  • liver problems
  • kidney problems
  • certain metabolic problem (porphyria)
  • certain hormonal conditions (adrenal/pituitary insufficiency, thyroid disease)

You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar. Rarely, alcohol can interact with gliclazide and cause a serious reaction with symptoms such as facial flushing, nausea, vomiting, dizziness, or stomach pain. If you notice any of these effects, tell your doctor right away.

It may be harder to control your blood sugar when your body is stressed (e.g., due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially low blood sugar.

This medication is not recommended for use during pregnancy. Consult your doctor for more details. Your doctor may switch you to insulin during your pregnancy.

It is not known whether this drug passes into breast milk, but it could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Beta blocker medications (e.g., metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness, hunger, or sweating, are unaffected by these drugs.

Check the labels on nonprescription/herbal products carefully. Some products contain sugar/alcohol and may affect your blood sugar. Ask your doctor or pharmacist about using these products safely.

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: shakiness, fast heartbeat, sweating, loss of consciousness.

Notes

Do not share this medication with others.

Attend a diabetes education program to learn more about how to manage your diabetes with medications, diet, exercise, and regular medical exams.

Lab and/or medical tests (such as kidney/liver function tests, fasting blood glucose, hemoglobin A1c, complete blood counts) should be done while you are taking this medication. Keep all medical and lab appointments. Check your blood sugar regularly as directed and share the results with your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store this medication at room temperature below 77 degrees F (25 degrees C) away from heat, light, and moisture. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets. Do not store in the bathroom.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Medical Alert

Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Is it an emergency?

If you or someone in your care has chest pains, difficulty breathing, or severe bleeding, it could be a life-threatening emergency. Call 9-1-1 or the local emergency number immediately.
If you are concerned about a possible poisoning or exposure to a toxic substance, call Poison Control now at 1-800-567-8911.

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