Avascular necrosis is bone death that occurs when the blood supply to the bones is decreased or stopped. Without an adequate blood supply, the bone breaks down and dies and collapses. If the bone affected is near a joint, the joint may also collapse. Although any bone can be affected, avascular necrosis most often affects ends of the long bones, such as the upper leg bone at the hip.
Avascular necrosis is also called osteonecrosis, aseptic necrosis, or ischemic bone necrosis.
What causes avascular necrosis?
An injury, such as a forceful impact in a car crash, or a complication of a hip fracture or dislocation can lead to avascular necrosis. Diseases such as sickle cell disease, gout, and lupus also may lead to avascular necrosis.
Long-term use of corticosteroids or drinking a large amount of alcohol over a long time increases the risk of avascular necrosis.
What are the symptoms?
Symptoms include mild to moderate hip or groin pain, decreased hip movement, and a limp. Pain may be sudden and become worse with standing or walking. Rest usually relieves the pain. Avascular necrosis occurs most often in men between 40 and 50 years old.
Children with avascular necrosis may have spasms in the hip muscle, have a limp, or refuse to bear weight. Legg-Calve-Perthes disease is a type of avascular necrosis in children that causes hip symptoms.
How is it treated?
Doctors usually start with treatments to limit further damage to the bone and joint and to help the bone to grow. Treatments may include medicines, exercises, and electrical stimulation as well as limiting weight-bearing on the joint. Anti-inflammatory drugs (NSAIDs) may be prescribed to reduce pain. Eventually, most people with avascular necrosis need surgery.
ByHealthwise Staff Primary Medical ReviewerWilliam H. Blahd, Jr., MD, FACEP - Emergency Medicine Brian O'Brien, MD, FRCPC - Internal Medicine Adam Husney, MD - Family Medicine Kathleen Romito, MD - Family Medicine Specialist Medical ReviewerKenneth J. Koval, MD - Orthopedic Surgery, Orthopedic Trauma