Treatment Overview

Radiation therapy uses radiation, such as X-rays, to destroy cancer cells. The radiation damages the genetic material of the cells so that they can't grow. Although radiation damages normal cells as well as cancer cells, the normal cells can repair themselves and function, while the cancer cells cannot.

Radiation therapy may be used alone or combined with hormonal treatment to treat prostate cancer. It is most effective in treating cancers that have not spread outside the prostate. But it also may be used if the cancer has spread to nearby tissue. Radiation is sometimes used after surgery to destroy any remaining cancer cells and to relieve pain from metastatic cancer.

Radiation is delivered in one of two ways.

• External-beam radiation therapy uses a large machine to aim a beam of radiation at your tumour. After the area of cancer is identified, an ink tattoo no bigger than a pencil tip is placed on your skin so that the radiation beam can be aimed at the same spot for each treatment. This helps focus the beam on your cancer to protect nearby healthy tissue from the radiation. External radiation treatments usually are done 5 days a week for 3 to 9 weeks. If cancer has spread to your bones, shorter periods of treatment may be given to specific areas to relieve pain.
  
  • Conformal radiotherapy (3D-CRT) uses a three-dimensional planning system to target a strong dose of radiation to the prostate cancer. This helps to protect healthy tissue from radiation.
  • Intensity-modulated radiation therapy (IMRT) uses a carefully adjusted amount of radiation. This protects healthy tissues more than conformal radiotherapy does.
• Brachytherapy, or internal radiation therapy, uses dozens of tiny seeds that contain radioactive material. It may be used to treat early-stage prostate cancer. Needles are used to insert the seeds through your skin into your prostate. The surgeon uses ultrasound to locate your prostate and guide the needles.
  
  • High-dose-rate (HDR) brachytherapy uses radioactive material placed into the prostate for a very brief period of time (seconds to minutes) before being removed. The radiation is delivered this way several times.
  • Low-dose-rate (LDR) brachytherapy uses a lower dose of radioactive material that is left in place temporarily or permanently.

Sometimes treatment combines brachytherapy with low-dose external radiation. In other cases, treatment combines surgery with external radiation or hormone therapy may be used along with brachytherapy.

Before radiation therapy is scheduled, your doctor probably will order a bone scan and CT scan to find out whether the cancer has spread to other parts of your body. If it has, your doctor may offer you the option of a clinical trial for treatment.

Radiation treatments to the prostate can injure the rectum, which is behind the prostate. One way to shield the rectum from much of the radiation to the prostate is with a hydrogel spacer. This is a water-based gel that is injected into the space between the prostate and the rectum before you have radiation treatments. The gel quickly becomes solid, and it stays solid for about 3 months. After that, it dissolves. This product may not be available in all areas.