Topic Overview

What is capsaicin?

Capsaicin is the ingredient found in different types of hot peppers, such as cayenne peppers, that makes the peppers spicy hot. You can eat it in raw or cooked peppers or as a dried powder, which you can add to food or drinks. It also is available as a natural health product and in topical creams that you apply to your skin.

What is capsaicin used for?

When a capsaicin cream or ointment is used on the skin (topical use), capsaicin helps relieve pain. Capsaicin works by first stimulating and then decreasing the intensity of pain signals in the body. Although pain may at first increase, it usually decreases after the first use. Capsaicin stimulates the release of a compound believed to be involved in communicating pain between the nerves in the spinal cord and other parts of the body.

When you apply it to the skin, capsaicin may help relieve pain from:

In general, you use creams containing capsaicin for pain relief. You can put the creams on your skin up to 4 times a day. You may feel a burning or itching sensation the first few times you use the cream, but this will gradually decrease with each use. Wash your hands thoroughly after each use to avoid getting the cream in your eyes or on other moist mucous membranes, where it can cause a burning sensation. Do not use the cream on areas of broken skin.

Supplement use

When you eat hot peppers or take capsaicin as a natural health product, the capsaicin may improve your digestion by increasing the digestive fluids in the stomach and by fighting bacteria that could cause an infection. It may also help fight diarrhea caused by bacterial infection.

Capsaicin may help prevent heart disease. It may stimulate the cardiovascular system and may lower blood cholesterol levels and blood pressure. It also helps prevent clotting and hardening of arteries (atherosclerosis).

Capsaicin acts as an antioxidant, protecting the cells of the body from damage by harmful molecules called free radicals. Capsaicin also may help prevent bacterial infections.

Capsaicin may also make mucus thinner and help move it out of the lungs. It is also thought to strengthen lung tissues and help to prevent or treat emphysema.

Is capsaicin safe?

Experts in Canada generally consider capsaicin to be safe. But it can cause some unpleasant effects, especially for those who are not used to it. Be careful when you cook with or eat hot peppers. Begin with small amounts, and increase the amount as you get used to it.

An allergic reaction to capsaicin is possible. If you are just beginning to use capsaicin, either as fresh or prepared food or in powder form, start with small amounts. If you use a topical cream, you should first apply it to a small area of skin to test for an allergic reaction.

Do not take capsaicin if you have high blood pressure or are already being treated for high blood pressure.

To reduce the burning sensation, remove the seeds from the peppers before you eat or cook with them. Also, if you eat bananas along with the peppers, you may reduce the burning sensation.

Extremely high intake of capsaicin may cause ulcers, but it's rare for anyone to consume enough for this to be a problem.

Don't let capsaicin come into contact with your eyes and other moist mucous membranes. After you touch capsaicin (or hot peppers), use vinegar or soap to wash your hands so you don't accidentally spread capsaicin to your eyes, nose, or mouth. You can also use disposable gloves to handle hot peppers or to apply capsaicin cream.

Do not apply capsaicin creams to areas of broken skin.

The Natural Health Products Directorate (NHPD), within the Health Products and Food Branch of Health Canada, regulates natural health products in Canada. Natural health products, including capsaicin, must be reviewed and approved by the NHPD before they can be sold in Canada.

Always tell your doctor if you are using a natural health product or if you are thinking about combining a natural health product with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a natural health product. This is especially important for women who are pregnant or breastfeeding.

When using natural health products, keep in mind the following:

  • Like conventional medicines, natural health products may cause side effects, trigger allergic reactions, or interact with prescription and non-prescription medicines or other natural health products you might be taking. A side effect or interaction with another medicine or natural health product may make other health conditions worse.
  • The way natural health products are manufactured may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of natural product that you buy in health food or grocery stores may not be the same as the form used in research.
  • Other than for vitamins and minerals, the long-term effects of most natural health products are not known.

Related Information


Other Works Consulted

  • Murray MT (2013). Capsicum frutescens (cayenne pepper). In JE Pizzorno, MT Murray, eds., Textbook of Natural Medicine, 4th ed., pp. 633–637. St. Louis: Mosby.
  • Capsicum peppers (2009). In A DerMarderosian et al., eds., Review of Natural Products. St. Louis: Wolters Kluwer Health.


ByHealthwise Staff
Primary Medical Reviewer Adam Husney, MD - Family Medicine
Brian D. O'Brien, MD - Internal Medicine
Specialist Medical Reviewer Kathleen Romito, MD - Family Medicine

Current as ofMay 22, 2015