Cholesterol Treatment Guidelines

Cholesterol Treatment Guidelines


The goal in treating cholesterol is to lower your chance of having a heart attack or a stroke. The goal is not to lower your cholesterol numbers alone.

The following guidelines are from the Canadian Cardiovascular Society (CCS).footnote 1

The two main types of treatment are:

  • Heart-healthy lifestyle.
  • Medicines called statins.

The way you choose to lower your risk will depend on how high your risk for heart attack and stroke is. It will also depend on how you feel about taking medicines. Your doctor can help you know your risk. Your doctor can help you balance the benefits and risks of your treatment options.

Heart-healthy lifestyle

A heart-healthy lifestyle is always important, even if you take medicines to lower your risk.

To be heart-healthy:

  • Eat heart-healthy foods.
  • Lose weight if you need to, and stay at a healthy weight.
  • Be active on most, if not all days of the week.
  • Don't smoke.
  • Manage other health problems.


You and your doctor can work together to understand your risks and what treatment is best for you. Your doctor may recommend that you take statins if the benefits outweigh the risks.

Statins strongly recommended for these people

Your doctor is likely to strongly recommend statins if you:

Statins recommended for these people

Your doctor is likely to recommend statins if:

  • Your LDL cholesterol is 5.0 mmol/L or above.
  • You have diabetes and any of the following is true:
    • You are age 40 or older.
    • You are age 30 or older and have had diabetes for more than 15 years.
    • Your diabetes has caused problems with your eyes, kidneys, or nerves.
  • Your risk of a heart attack or stroke is 10% or greater and either your cholesterol is 3.5 mmol/L or above or you have certain other risk factors. .

Statins not as clearly recommended for these people

For some people, it's not as clear if they need to take a statin. You and your doctor will need to look at your overall health and any other risks you have for heart attack and stroke.

When deciding about medicines, you and your doctor may think about:

  • Having a risk for heart attack or stroke between 5 and 9% even though the LDL cholesterol test result is less than 5.0 mmol/L
  • A high LDL cholesterol test result (160 mg/dL or higher).
  • Results of tests such as C-reactive protein, coronary calcium scan, or ankle-brachial index.
  • Your lifetime risk of heart attack and stroke.

Other medicines

Your doctor may talk with you about also taking a cholesterol absorption inhibitor or a PCSK9-inhibitor. These medicines can also reduce the risk of heart attack and stroke for some people. These medicines may be taken along with a statin.

Other medicines can improve cholesterol and triglyceride levels, but they have not been proven to lower the risk of a heart attack or a stroke. These medicines include bile acid sequestrants, fibric acid derivatives, and nicotinic acid (niacin).



  1. Anderson TJ, et al. (2016). 2016 Canadian Cardiovascular Society guidelines for the management of dyslipidemia for the prevention of cardiovascular disease in the adult. Canadian Journal of Cardiology, 32(11): 1263–1282. DOI: 10.1016/j.cjca.2016.07.510. Accessed October 20, 2018.


Current as of: September 7, 2022

Author: Healthwise Staff
Medical Review:
Kathleen Romito MD - Family Medicine
E. Gregory Thompson MD - Internal Medicine
Martin J. Gabica MD - Family Medicine
Adam Husney MD - Family Medicine