Statins and Statin Combinations for High Cholesterol
|Generic Name||Brand Name|
|Generic Name||Brand Name|
|atorvastatin and amlodipine, a calcium channel blocker for high blood pressure||Caduet|
How It Works
Statins may be taken alone or taken with other cholesterol medicines such as fibric acid derivatives, bile acid sequestrants, or nicotinic acid. Statins may also be combined with other types of medicines into one pill.
Why It Is Used
How Well It Works
Statins and statin combinations can:
- Lower the risk of heart attack. footnote 1
- Lower stroke risk. footnote 1
- Reduce LDL by 18% to 55%.footnote 2 This means that if your LDL is 5.1, taking a statin could lower your LDL to between 4.2 and 2.3.
- Increase HDL by 5% to 15%.footnote 2 This means that if your HDL is 1.5, taking a statin could increase your HDL to between 1.6 and 1.8. The higher your HDL, the better. An HDL of 1.5 and higher is linked with a lower risk of heart disease.
- Reduce triglycerides by 7% to 30%.footnote 2 This means that if your triglycerides are 2.3, taking a statin could lower your triglycerides to between 2.1 and 1.6.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
- Usually the benefits of the medicine are more important than any minor side effects.
- Side effects may go away after you take the medicine for a while.
- If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call 911 or other emergency services right away if you have:
- Trouble breathing.
- Swelling of your face, lips, tongue, or throat.
Call your doctor right away if you have hives.
Call your doctor right away if you have symptoms of a rare muscle problem called rhabdomyolysis:
- Severe muscle pain, tenderness, or weakness.
- Dark-coloured urine.
The most common side effect of statins is muscle aches. A less common side effect is diabetes. Statins may slightly raise the risk of diabetes in some people.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Before taking this medicine, tell your doctor all of the medicines you are taking, including over-the-counter medicines, vitamins, or natural health products.
If you have muscle aches when you start this medicine, tell your doctor. The aches may go away with time. Or you might be able to try a lower dose or a different statin medicine.
Be active and eat a cholesterol-lowering diet in addition to taking this medicine. Ask your doctor for advice on a diet that can help lower cholesterol.
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
Do not use this medicine if you are pregnant, breastfeeding, or planning to get pregnant. If you need to take this medicine, talk to your doctor about how you can prevent pregnancy.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
- Drugs for lipids (2011). Treatment Guidelines From The Medical Letter, 9(103): 13–20.
- Grundy SM, et al. (2001). Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285(19): 2486–2497.
Primary Medical Reviewer Kathleen Romito, MD - Family Medicine
Donald Sproule, MDCM, CCFP - Family Medicine
Martin J. Gabica, MD - Family Medicine
Specialist Medical Reviewer Robert A. Kloner, MD, PhD - Cardiology
Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology
Adam Husney, MD - Family Medicine
Current as ofJuly 27, 2016
Current as of: July 27, 2016
Author: Healthwise Staff
Medical Review: Kathleen Romito, MD - Family Medicine & Donald Sproule, MDCM, CCFP - Family Medicine & Martin J. Gabica, MD - Family Medicine & Robert A. Kloner, MD, PhD - Cardiology & Rakesh K. Pai, MD, FACC - Cardiology, Electrophysiology & Adam Husney, MD - Family Medicine
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