Timolol/Latanoprost - Ophthalmic

Pronunciation: TIM-oh-lol/la-TAN-oh-prost

Common Brand Name(s): Xalacom

Important: How To Use This Information

This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.


This product contains 2 medications used to reduce high pressure in the eye caused by glaucoma (open angle-type) or other eye conditions (such as ocular hypertension). Lowering high pressure inside the eye helps to prevent vision loss. Timolol belongs to a class of drugs known as beta blockers. Latanoprost belongs to a class of drugs known as prostaglandins.

How To Use

Read the Patient Information Leaflet if available from your pharmacist before you start using this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is for use in the affected eye(s), usually once daily or as directed by your doctor.

To apply eye drops, wash your hands first.

To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

The preservative in this product may be absorbed by contact lenses. If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes after using this medication before replacing your contact lenses.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, place one finger at the corner of your eye (near the nose) and apply gentle pressure to prevent the medication from draining out. Wait 2 to 3 minutes before opening your eyes. Try not to blink and do not rub your eyes. Repeat these steps for your other eye if so directed by your doctor.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (such as drops or ointment), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day.

Do not increase your dose or use this medication more often than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not have symptoms.

Side Effects

Temporary blurred vision, burning/itching/redness in the eye, dry eyes, watery eyes, feeling as if something is in the eye, increase in eyelash number/color/length/thickness, eyelid changes/skin darkening, eyelid crusting/discomfort, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication may slowly (over months to years) cause brown discoloration/darkening of the colored portion of the eye (iris). If you are using this medication in only one eye, only that iris may change color. This color change may be permanent and the long-term effects are uncertain. Tell your doctor if this occurs and schedule regular eye exams to monitor it.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur:

  • eye pain/discomfort in bright light (photophobia)
  • slow/irregular heartbeat
  • signs of low blood pressure (such as dizziness/fainting)
  • mental/mood changes (such as depression)
  • coldness/numbness/pain in the hands or feet

Seek immediate medical attention if any of these rare but serious side effects occur:

  • sudden vision change
  • trouble breathing
  • signs of new/worsening heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain)
  • symptoms of a heart attack (such as chest/jaw/left arm pain, unusual sweating)
  • signs of a stroke (such as weakness on one side of the body, slurred speech, confusion)

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • severe itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using this product, tell your doctor or pharmacist if you are allergic to timolol or latanoprost; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • other eye problems (such as iritis, uveitis, macular edema, lens extraction/aphakia, herpes infection of the eye)
  • lung disease/breathing problems (such as current or past medical history of asthma, chronic obstructive pulmonary disease)
  • slow/irregular heartbeat
  • heart problems (such as chest pain, heart failure)
  • low blood pressure
  • diabetes
  • blood circulation problems
  • overactive thyroid disease (hyperthyroidism)
  • a certain muscle/nerve disease (myasthenia gravis)
  • severe allergic reactions (such as anaphylaxis, atopy)

If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of timolol/latanoprost. You may be advised to start using a new bottle.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may cause temporary blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

If you have diabetes, this product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Timolol passes into breast milk. It is unknown if latanoprost passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include:

  • beta blockers (such as atenolol, propranolol)
  • eyelash treatment (such as bimatoprost)
  • epinephrine
  • fingolimod


This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: trouble breathing, slow/irregular heartbeat.


Do not share this medication with others.

Laboratory and/or medical tests (such as eye exams, pulse/heart rate monitoring) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, use it as soon as you remember if it is on the same day. If you do not remember until the next day, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.


Store the unopened bottle in the refrigerator between 36-46 degrees F (2-8 degrees C). Protect from light.

Once opened, the container may be stored at room temperature at or below 77 degrees F (25 degrees C), away from light and moisture. Do not freeze. Do not store in the bathroom. Discard container 10 weeks after opening. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Is it an emergency?

If you or someone in your care has chest pains, difficulty breathing, or severe bleeding, it could be a life-threatening emergency. Call 9-1-1 or the local emergency number immediately.
If you are concerned about a possible poisoning or exposure to a toxic substance, call Poison Control now at 1-800-567-8911.

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