Insulin for Gestational Diabetes



Generic Name Brand Name
insulin aspart NovoRapid
insulin lispro Humalog


Generic Name Brand Name
insulin regular Humulin R, Novolin ge Toronto


Generic Name Brand Name
insulin NPH Humulin N, Novolin ge NPH


Generic Name Brand Name
insulin glargine Lantus


Generic Name Brand Name
insulin regular/insulin NPH Humulin 30/70, Novolin ge 30/70, Novolin ge 40/60, Novolin ge 50/50
insulin lispro/lispro protamine Humalog Mix25, Humalog Mix50
insulin aspart/aspart protamine Novomix 30
Generic Name Brand Name
50% lispro protamine and 50% lispro Humalog Mix 50/50
50% NPH and 50% regular Humulin 50/50
70% aspart protamine and 30% aspart NovoLog Mix 70/30
70% NPH and 30% regular Humulin 70/30, Novolin 70/30
75% lispro protamine and 25% lispro Humalog Mix 75/25

Insulin normally is made by the pancreas, a gland behind the stomach. The medicine form of insulin helps the body use glucose. Insulin cannot be taken as a pill, because stomach acid destroys insulin before it can enter the blood.

Insulin is categorized according to how fast it starts to work and how long it continues to work. The types of insulin available include rapid-, short-, intermediate-, and long-acting insulin. See types of insulin for more information.


Insulin is packaged in small glass bottles that are sealed with rubber lids. One bottle of U-100 insulin holds 1,000 units, which is many doses of insulin. It is also packaged in small cartridges used in pen-shaped devices ( insulin pens ) attached to disposable needles. Insulin bottles and cartridges are labelled with important information you should read, such as the expiration date.

How insulin is taken

Insulin usually is given as a shot under the skin. It can also be given through an insulin pump or a jet injector, a device that sprays the medicine into the skin. Some insulins can be given in a vein, but this is only done in a hospital.

How It Works

Insulin reduces blood sugar levels by helping sugar (glucose) enter the cells to be used for energy. Sometimes women who have gestational diabetes need to take two types of insulin, usually a rapid- or short-acting and an intermediate-acting type.

  • The short-acting insulin reduces blood sugar levels quickly and then wears off.
  • The combination of a rapid- or short-acting and intermediate-acting insulin helps keep blood sugar levels in a target range both before and after meals.

Why It Is Used

You may need to take insulin to keep your blood sugar in a target range. Keeping your blood sugar in a target range is the best way to prevent problems from gestational diabetes, such as a baby who grows too large or a baby who is born with low blood sugar. Usually, gestational diabetes goes away after your baby is born. Then you no longer need insulin.

How Well It Works

Insulin is effective in reducing blood sugar levels by helping sugar (glucose) enter the cells to be used for energy.

Side Effects

All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

  • Usually the benefits of the medicine are more important than any minor side effects.
  • Side effects may go away after you take the medicine for a while.
  • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

  • Trouble breathing.
  • Swelling of your face, lips, tongue, or throat.
  • Passed out (lost consciousness) or suddenly become very sleepy or confused. You may have low blood sugar, called hypoglycemia.

Call your doctor if:

  • You have hives.
  • You often have problems with high or low blood sugar levels.

Common side effects of this medicine include:

  • Low blood sugar.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

What you need to know

Insulin will work faster if:

  • It is accidentally injected into a muscle instead of into fatty tissue.
  • You have just exercised the muscles in the area where you give your insulin injection.
  • You put a heat pack on or massage the area where you have just given your insulin injection.

To learn how to prepare and give insulin injections, see:

Gestational Diabetes: Giving Yourself Insulin Shots.

Things to check

Always check the expiration date on the bottle.

Insulin should be stored properly. If it is not, it may break down and not work very well.

Taking medicine

Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.

There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.


Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.


ByHealthwise Staff

Primary Medical Reviewer Kathleen Romito, MD - Family Medicine

Thomas M. Bailey, MD - Family Medicine

Specialist Medical Reviewer Lois Jovanovic, MD - Endocrinology

Current as ofMay 22, 2015