Sickle Cell Disorders
Sickle Cell Disorders
- Sickle cell disease (hemoglobin SS disease) occurs when both genes produce hemoglobin S. This person typically has symptoms of anemia , mild to life-threatening complications, and a shortened lifespan.
- Sickle beta-thalassemia occurs when a person has one hemoglobin S gene and another gene that causes the body to produce less hemoglobin than normal. This person may have mild to severe sickle cell disease.
- Hemoglobin SC disease occurs when a person has one hemoglobin S gene and one abnormal hemoglobin C gene. This person may have generally milder symptoms and a longer lifespan than a person with sickle cell disease but still may become seriously ill.
- Hemoglobin SE disease occurs when a person has one hemoglobin S gene and one abnormal hemoglobin E gene. This person may have mild anemia. Most people do not have symptoms.
- Hemoglobin SO disease and hemoglobin SD disease occur when a person has one hemoglobin S gene and one abnormal hemoglobin O or hemoglobin D gene. This person may experience all sickle cell disease symptoms, ranging from mild to severe.
Other Works Consulted
- Natarajan K, et al. (2010). Disorders of hemoglobin structure: Sickle cell anemia and related abnormalities. In K Kaushansky et al., eds., Williams Hematology, 8th ed., pp. 709–741. New York: McGraw-Hill.
- Steinberg MH (2012). Sickle cell disease and other hemoglobinopathies. In L Goldman, A Shafer, eds., Goldman's Cecil Medicine, 24th ed., pp. 1066–1075. Philadelphia: Saunders.
- Wang WC (2009). Sickle cell anemia and other sickling syndromes. In JP Greer et al., eds., Wintrobe's Clinical Hematology, 12th ed., pp. 1038–1082. Philadelphia: Lippincott Williams and Wilkins.
Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
Donald Sproule, MDCM, CCFP - Family Medicine
Specialist Medical Reviewer Martin Steinberg, MD - Hematology
Current as ofFebruary 20, 2015
Public Health Alerts
Public health alerts include information about outbreaks, advisories and product recalls. Click on the links below to read the most recent alerts, or visit our Public Health Alerts web page.
Want More Information?
HealthLink BC, your provincial health line, is as close as your phone or the web any time of the day or night, every day of the year.
Call 8-1-1 toll-free in B.C. or for deaf and hearing-impaired, call 7-1-1.
You can speak with a health service representative, who can also connect you with a:
- registered nurse any time, every day of the year;
- registered dietitian from 9am to 5pm, Monday to Friday;
- pharmacist from 5pm to 9am, every day of the year.
Translation services are available in more than 130 languages.
FIND Services and Resources
If you are looking for health services in your community, you can use our directory to FIND hospitals, clinics, and other resources.
To learn more about Healthwise, visit Healthwise.org
© 1995-2015 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
Is it an emergency?
If you or someone in your care has chest pains, difficulty breathing, or severe bleeding, it could be life-threatening. Call 9-1-1 or the local emergency number immediately. If you are concerned about a possible poisoning or exposure to a toxic substance, call Poison Control now at 1-800-567-8911.