St. John's Wort
St. John's Wort
What is St. John's wort?
St. John's wort (Hypericum perforatum) is a plant with yellow flowers that people in European countries have used for centuries to treat mild to moderate depression . In Canada, it is sold as a natural health product and can be found at health food stores and pharmacies.
What is St. John's wort used for?
St. John's wort is used in the short-term treatment of mild to moderate depression.
It may take up to 2 to 3 weeks for St. John's wort to improve depressive symptoms. Not all preparations of St. John's wort are the same. A standardized form means the amount of St. John's wort is the same in every capsule.
Is St. John's wort safe?
St. John's wort causes fewer side effects (such as digestive discomfort or headaches) than antidepressant medicines, although it may cause a rash with sun exposure.
St. John's wort may interact with medicines used to treat some other illnesses, such as AIDS . It is important to let your doctor or pharmacist know if you want to try St. John's wort so that he or she can determine whether it might interfere with other medicines you are taking.
- Do not take St. John's wort while you are taking other antidepressants. You may overmedicate yourself, resulting in serious negative side effects. Always talk with your doctor before you take any herbal remedies to treat depression or other conditions.
- Do not take St. John's wort while you are taking protease inhibitors (PIs) or nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infection .
- Do not take St. John's wort while you are pregnant or breast-feeding.
The Natural Health Products Directorate (NHPD), within the Health Products and Food Branch of Health Canada, regulates natural health products in Canada. Natural health products, including St. John's wort, must be reviewed and approved by the NHPD before they can be sold in Canada.
Always tell your doctor if you are using a natural health product or if you are thinking about combining a natural health product with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a natural health product. This is especially important for women who are pregnant or breast-feeding.
When using natural health products, keep in mind the following:
- Like conventional medicines, natural health products may cause side effects, trigger allergic reactions, or interact with prescription and non-prescription medicines or other natural health products you are taking. A side effect or interaction with another medicine or natural product may make other health conditions worse.
- Natural health products may not be standardized in their manufacturing. This means that how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form you buy in health food or grocery stores may not be the same as the form used in research.
- The long-term effects of most natural health products, other than vitamins and minerals, are not known. Many natural health products are not used long-term.
Other Works Consulted
- St. John’s wort (2010). In A DerMarderosian et al., eds., Review of Natural Products. St. Louis: Wolters Kluwer Health.
- Bongiorno PB, Murray MT (2013). Hypericum perforatum (St. John's wort). In JE Pizzorno, MT Murray, eds., Textbook of Natural Medicine, 4th ed., pp. 833–841. St. Louis: Mosby.
- Linde K, et al. (2008). St. John's wort for major depression. Cochrane Database of Systematic Reviews (4).
- Szegedi A, et al. (2005). Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St. John's wort): Randomised controlled double blind non-inferiority trial versus paroxetine. BMJ, 330(7490): 503–508.
Primary Medical Reviewer Adam Husney, MD - Family Medicine
Brian D. O'Brien, MD - Internal Medicine
Specialist Medical Reviewer Kathleen Romito, MD - Family Medicine
Current as ofMay 22, 2015
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