Antibiotics to Treat and Prevent Infection During Preterm Labour

Topic Overview

During preterm labour, antibiotics may be used to treat or prevent an infection.

Treatment with antibiotics

If an infection is causing your preterm labour, you will be treated with antibiotics . The type used depends on which bacteria are causing the infection. The antibiotics most commonly used during pregnancy include erythromycin, clindamycin, ampicillin, gentamicin, and metronidazole.

Antibiotics don't always clear up uterine infection. And they don't always prevent preterm labour . If a mother's uterus has become infected and her fetus is mature enough, her doctor or nurse-midwife might not try to delay the birth.

Prevention with antibiotics after pPROM

Preterm premature rupture of membranes (pPROM) means that your water breaks (rupture of the amniotic sac) before 37 completed weeks of pregnancy. When given to women with pPROM, antibiotics may: footnote 1

  • Increase time from pPROM to delivery.
  • Lower the risk of infection in the vagina and uterus.
  • Lower the risk of fetal infection.

Prevention with antibiotics with intact membranes

Antibiotics are not a recommended treatment for women in preterm labour with intact membranes. (This means the amniotic sac has not ruptured.) But some women do get antibiotics to prevent or treat group B strep .

Related Information



  1. Haas DM (2011). Preterm birth, search date June 2010. BMJ Clinical Evidence. Available online:


ByHealthwise Staff

Primary Medical Reviewer Sarah Marshall, MD - Family Medicine

Thomas M. Bailey, MD - Family Medicine

Specialist Medical Reviewer William Gilbert, MD - Maternal and Fetal Medicine

Current as ofNovember 14, 2014